PDB entry 4kh1

View 4kh1 on RCSB PDB site
Description: The R state structure of E. coli ATCase with CTP,UTP, and Magnesium bound
Class: transferase
Keywords: pyrimidine nucleotide biosynthesis, feedback inhibition, competing pathway product activation, allostery, TRANSFERASE
Deposited on 2013-04-29, released 2013-11-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-11-27, with a file datestamp of 2013-11-22.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.164
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aspartate carbamoyltransferase
    Species: Escherichia coli [TaxId:595495]
    Gene: pyrB, EKO11_4066, KO11_22860
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kh1a1, d4kh1a2
  • Chain 'B':
    Compound: Aspartate carbamoyltransferase regulatory chain
    Species: Escherichia coli [TaxId:595495]
    Gene: pyrI, EKO11_4067, KO11_22855
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kh1b1, d4kh1b2
  • Chain 'C':
    Compound: aspartate carbamoyltransferase
    Species: Escherichia coli [TaxId:595495]
    Gene: pyrB, EKO11_4066, KO11_22860
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kh1c1, d4kh1c2
  • Chain 'D':
    Compound: Aspartate carbamoyltransferase regulatory chain
    Species: Escherichia coli [TaxId:595495]
    Gene: pyrI, EKO11_4067, KO11_22855
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kh1d1, d4kh1d2
  • Heterogens: PAL, ZN, CTP, UTP, MG, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4kh1A (A:)
    anplyqkhiisindlsrddlnlvlataaklkanpqpellkhkviascffeastrtrlsfe
    tsmhrlgasvvgfsdsantslgkkgetladtisvistyvdaivmrhpqegaarlatefsg
    nvpvlnagdgsnqhptqtlldlftiqetqgrldnlhvamvgdlkygrtvhsltqalakfd
    gnrfyfiapdalampqyildmldekgiawslhssieevmaevdilymtrvqkerldpsey
    anvkaqfvlrasdlhnakanmkvlhplprvdeiatdvdktphawyfqqagngifarqall
    alvlnrdlvl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4kh1B (B:)
    mthdnklqveaikrgtvidhipaqigfkllslfkltetdqritiglnlpsgemgrkdlik
    ientflsedqvdqlalyapqatvnridnyevvgksrpslperidnvlvcpnsncishaep
    vsssfavrkrandialkckycekefshnvvlan
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kh1B (B:)
    lqveaikrgtvidhipaqigfkllslfkltetdqritiglnlpsgemgrkdlikientfl
    sedqvdqlalyapqatvnridnyevvgksrpslperidnvlvcpnsncishaepvsssfa
    vrkrandialkckycekefshnvvlan
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4kh1C (C:)
    anplyqkhiisindlsrddlnlvlataaklkanpqpellkhkviascffeastrtrlsfe
    tsmhrlgasvvgfsdsantslgkkgetladtisvistyvdaivmrhpqegaarlatefsg
    nvpvlnagdgsnqhptqtlldlftiqetqgrldnlhvamvgdlkygrtvhsltqalakfd
    gnrfyfiapdalampqyildmldekgiawslhssieevmaevdilymtrvqkerldpsey
    anvkaqfvlrasdlhnakanmkvlhplprvdeiatdvdktphawyfqqagngifarqall
    alvlnrdlvl
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4kh1D (D:)
    mthdnklqveaikrgtvidhipaqigfkllslfkltetdqritiglnlpsgemgrkdlik
    ientflsedqvdqlalyapqatvnridnyevvgksrpslperidnvlvcpnsncishaep
    vsssfavrkrandialkckycekefshnvvlan
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kh1D (D:)
    lqveaikrgtvidhipaqigfkllslfkltetdqritiglnlpsgemgrkdlikientfl
    sedqvdqlalyapqatvnridnyevvgksrpslperidnvlvcpnsncishaepvsssfa
    vrkrandialkckycekefshnvvlan