PDB entry 4kbc

View 4kbc on RCSB PDB site
Description: CK1d in complex with {4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}METHANOL inhibitor
Class: transferase/transferase inhibitor
Keywords: ser/thr kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-04-23, released 2013-09-18
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: 0.186
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kbca_
  • Chain 'B':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kbcb_
  • Heterogens: 1QJ, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4kbcA (A:)
    melrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmq
    ggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyih
    sknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtarya
    sinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievl
    ckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlkfgasra
    addaererrdreerlrh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kbcA (A:)
    elrvgnryrlgrkigsdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgi
    ptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfi
    hrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinth
    lgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgyp
    sefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4kbcB (B:)
    melrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmq
    ggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyih
    sknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtarya
    sinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievl
    ckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlkfgasra
    addaererrdreerlrh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kbcB (B:)
    melrvyrlgrkigsgsfgdiylgtdiaageevaiklekhpqlhieskiykmmqggvgipt
    irwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihr
    dvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlg
    ieqsrrddleslgyvlmyfnlgslpwqglkyerisekkmstpievlckgypsefatylnf
    crslrfddkpdysylrqlfrnlfhrqgfsydyvfdwn