PDB entry 4kb8

View 4kb8 on RCSB PDB site
Description: CK1d in complex with 1-{4-[3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOL-4-YL]PYRIDIN-2-YL}-N-METHYLMETHANAMINE ligand
Class: transferase/transferase inhibitor
Keywords: ser/thr kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-04-23, released 2013-09-18
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.207
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kb8a_
  • Chain 'B':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kb8b_
  • Chain 'C':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kb8c_
  • Chain 'D':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kb8d_
  • Heterogens: 1QN, SO4, 1QO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4kb8A (A:)
    mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
    pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
    lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
    yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
    risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
    vfdwnmlkfgasraaddaererrdreerlrh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kb8A (A:)
    lrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqgg
    vgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsk
    nfihrdvkpdnflmglgkkgnlvyiidfglakkygtaryasinthlgieqsrrddleslg
    yvlmyfnlgslpwqglkerisekkmstpievlckgypsefatylnfcrslrfddkpdysy
    lrqlfrnlfhrqgfsydyvfdwnml
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4kb8B (B:)
    mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
    pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
    lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
    yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
    risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
    vfdwnmlkfgasraaddaererrdreerlrh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kb8B (B:)
    lrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecqlhieskiykmmqggvgipti
    rwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihrd
    vkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlgi
    eqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsef
    atylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4kb8C (C:)
    mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
    pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
    lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
    yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
    risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
    vfdwnmlkfgasraaddaererrdreerlrh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kb8C (C:)
    nryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgip
    tirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfih
    rdvkpdnflmglgkkgnlvyiidfglakkyyrenknltgtaryasinthlgieqsrrddl
    eslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatylnfcr
    slrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4kb8D (D:)
    mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
    pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
    lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
    yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
    risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
    vfdwnmlkfgasraaddaererrdreerlrh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kb8D (D:)
    lrvgnryrlgrkigdiylgtdiaageevaiklecpqlhieskiykmmqggvgiptirwcg
    aegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihrdvkpd
    nflmglgkkgnlvyiidfglakkyrdaqhipyrenknltgtaryasinthlgieqsrrdd
    leslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatylnfc
    rslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml