PDB entry 4k33
View 4k33 on RCSB PDB site
Description: Crystal Strucure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma
Class: transferase
Keywords: Kinase Domain Fold Consisting of N- and C-lobes, Receptor Tyrosine Kinase, TRANSFERASE
Deposited on
2013-04-10, released
2013-09-11
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-10-30, with a file datestamp of
2013-10-25.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: 0.181
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Fibroblast growth factor receptor 3
Species: Homo sapiens [TaxId:9606]
Gene: FGFR3, JTK4
Database cross-references and differences (RAF-indexed):
- Uniprot P22607
- engineered mutation (47)
- engineered mutation (147)
- engineered mutation (215)
Domains in SCOPe 2.05: d4k33a_ - Heterogens: ACP, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4k33A (A:)
mgsshhhhhhsqdpptlanvselelpadpkwelsrarltlgkplgegafgqvvmaeaigi
dkdraakpvtvavkmlkddatdkdlsdlvsememmkmigkhkniinllgactqggplyvl
veyaakgnlreflrarrppgldysfdtskppeeqltfkdlvscayqvargmeylasqkci
hrdlaarnvlvtednvmkiadfglardvhnldyykettngrlpvkwmapealfdrvythq
sdvwsfgvllweiftlggspypgipveelfkllkeghrmdkpancthdlymimrecwhaa
psqrptfkqlvedldrvltvtstde
Sequence, based on observed residues (ATOM records): (download)
>4k33A (A:)
lpadpkwelsrarltlgkplgegafgqvvmaeaigidkdraakpvtvavkmlkddatdkd
lsdlvsememmkmigkhkniinllgactqggplyvlveyaakgnlreflrarrppgldys
fdtseqltfkdlvscayqvargmeylasqkcihrdlaarnvlvtednvmkiadfglardv
hnldyykettngrlpvkwmapealfdrvythqsdvwsfgvllweiftlggspypgipvee
lfkllkeghrmdkpancthdlymimrecwhaapsqrptfkqlvedldrvltvt