PDB entry 4jxh

View 4jxh on RCSB PDB site
Description: Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at pH 8.5
Class: signaling protein/inhibitor
Keywords: sec 7 domain, NUCLEOTIDE EXCHANGE FACTOR, ARF1, SIGNALING PROTEIN-INHIBITOR complex
Deposited on 2013-03-28, released 2013-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-23, with a file datestamp of 2014-04-18.
Experiment type: XRAY
Resolution: 1.47 Å
R-factor: 0.135
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytohesin-2
    Species: Homo sapiens [TaxId:9606]
    Gene: CYTH2, ARNO, PSCD2, PSCD2L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99418 (21-End)
      • expression tag (20)
    Domains in SCOPe 2.08: d4jxha1, d4jxha2
  • Heterogens: HRC, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jxhA (A:)
mgsshhhhhhssglvprgshmsktlqrnrkmamgrkkfnmdpkkgiqflvenellqntpe
eiarflykgeglnktaigdylgereelnlavlhafvdlheftdlnlvqalrqflwsfrlp
geaqkidrmmeafaqryclcnpgvfqstdtcyvlsfavimlntslhnpnvrdkpglerfv
amnrgineggdlpeellrnlydsirnepfkipeddgn

    Sequence, based on observed residues (ATOM records): (download) 
    >4jxhA (A:)
msktlqrnrkmamgrkkfnmdpkkgiqflvenellqntpeeiarflykgeglnktaigdy
lgereelnlavlhafvdlheftdlnlvqalrqflwsfrlpgeaqkidrmmeafaqryclc
npgvfqstdtcyvlsfavimlntslhnpnvrdkpglerfvamnrgineggdlpeellrnl
ydsirnepfkipedd