PDB entry 4jwr

View 4jwr on RCSB PDB site
Description: Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid
Class: ligase/ligase inhibitor
Keywords: p53, protein-protein interaction, LIGASE-LIGASE INHIBITOR complex
Deposited on 2013-03-27, released 2013-05-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-06-05, with a file datestamp of 2013-05-31.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.236
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jwra_
  • Chain 'B':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jwrb_
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jwrc_
  • Heterogens: 1MY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jwrA (A:)
sqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >4jwrA (A:)
ipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydhivycsndll
gdlfgvpsfsvkehrkiytmiyrnlvvv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jwrB (B:)
sqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >4jwrB (B:)
ipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydhivycsndll
gdlfgvpsfsvkehrkiytmiyrnlvvv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4jwrC (C:)
sqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivy
csndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >4jwrC (C:)
ipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydhivycsndll
gdlfgvpsfsvkehrkiytmiyrnlvvv