PDB entry 4jvr

View 4jvr on RCSB PDB site
Description: Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Class: ligase/ligase inhibitor
Keywords: p53, protein-protein interaction, LIGASE-LIGASE INHIBITOR complex
Deposited on 2013-03-26, released 2013-05-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-06-05, with a file datestamp of 2013-05-31.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.256
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jvra_
  • Chain 'C':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jvrc_
  • Chain 'E':
    Compound: E3 ubiquitin-protein ligase Mdm2
    Species: Homo sapiens [TaxId:9606]
    Gene: MDM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jvre_
  • Heterogens: 1MT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4jvrA (A:)
    qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
    sndllgdlfgvpsfsvkehrkiytmiyrnlvvvngs
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jvrA (A:)
    qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydhivycsndl
    lgdlfgvpsfsvkehrkiytmiyrnlvvv
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4jvrC (C:)
    qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
    sndllgdlfgvpsfsvkehrkiytmiyrnlvvvngs
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jvrC (C:)
    qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydhivycsndl
    lgdlfgvpsfsvkehrkiytmiyrnlvvv
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4jvrE (E:)
    qipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlydekqqhivyc
    sndllgdlfgvpsfsvkehrkiytmiyrnlvvvngs
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jvrE (E:)
    ipaseqetlvrpkplllkllksvgqkdtytmkevlfylgqyimtkrlydqhivycsndll
    gdlfgvpsfsvkehrkiytmiyrnlvvv