PDB entry 4jtw

View 4jtw on RCSB PDB site
Description: Crystal structure of HCV NS5B polymerase in complex with coupound 1
Class: transferase/transferase inhibitor
Keywords: RNA-directed RNA polymerase, transferase, transferase-transferase inhibitor complex
Deposited on 2013-03-24, released 2013-07-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-26, with a file datestamp of 2014-03-21.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.2
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Genome polyprotein
    Species: HEPATITIS C VIRUS [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4jtwa_
  • Chain 'B':
    Compound: Genome polyprotein
    Species: HEPATITIS C VIRUS [TaxId:420174]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4jtwb_
  • Heterogens: GOL, 1NU, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jtwA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrarprhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtwA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jtwB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhslsrarprhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtwB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyhs