PDB entry 4jti

View 4jti on RCSB PDB site
Description: Crystal structure of F114R/R117Q/F139G mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Class: transferase
Keywords: manno-octulosonate, synthase, lipopolysaccharide, kdop, kdo8 kdops, kdo8ps, tim barrel, transferase, lipopolysaccharide biosynthesis
Deposited on 2013-03-23, released 2013-06-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-12-18, with a file datestamp of 2013-12-13.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.16
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (113)
      • engineered mutation (116)
      • engineered mutation (138)
    Domains in SCOPe 2.08: d4jtia_
  • Chain 'B':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (113)
      • engineered mutation (116)
      • engineered mutation (138)
    Domains in SCOPe 2.08: d4jtib_
  • Chain 'C':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (113)
      • engineered mutation (116)
      • engineered mutation (138)
    Domains in SCOPe 2.08: d4jtic_
  • Chain 'D':
    Compound: 2-dehydro-3-deoxyphosphooctonate aldolase
    Species: Neisseria meningitidis [TaxId:122586]
    Gene: kdsA, NMB1283
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9JZ55 (0-End)
      • engineered mutation (113)
      • engineered mutation (116)
      • engineered mutation (138)
    Domains in SCOPe 2.08: d4jtid_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jtiA (A:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
pklakcdgpsalplhlledflirikalddliksqpiltie

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtiA (A:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrgrraqaldlalagmatrlaglfleslhlledfliri
kalddliksqpil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jtiB (B:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
pklakcdgpsalplhlledflirikalddliksqpiltie

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtiB (B:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrggrraqaldlalagmatrlaglflesplhlledfli
rikalddliksqpilti

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4jtiC (C:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
pklakcdgpsalplhlledflirikalddliksqpiltie

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtiC (C:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrgrraqaldlalagmatrlaglfleshpalplhlled
flirikalddliksqpil

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4jtiD (D:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrdagsaasggrraqaldlalagmatrlaglfleshpd
pklakcdgpsalplhlledflirikalddliksqpiltie

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtiD (D:)
mdikinditlgnnspfvlfgginvlesldstlqtcahyvevtrklgipyifkasfdkanr
ssihsyrgvgleeglkifekvkaefgipvitdvhephqcqpvaevcdviqlparlaqqtd
lvvamaktgnvvnikkpqglspsqmknivekfheagngklilcergssfgydnlvvdmlg
fgvmkqtcgnlpvifdvthslqtrgrraqaldlalagmatrlaglfleshpalplhlled
flirikalddliksqpil