PDB entry 4jsr

View 4jsr on RCSB PDB site
Description: Crystal Structure of human SIRT3 with ELT inhibitor 11c [N-{2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl}-N'-ethylthiophene-2,5-dicarboxamide]
Class: hydrolase/hydrolase inhibitor
Keywords: Deacetylase, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2013-03-22, released 2013-04-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-07-03, with a file datestamp of 2013-06-28.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.2
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT3, SIR2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jsra_
  • Heterogens: ZN, 1NQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jsrA (A:)
snasdkgklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlp
ypeaifelpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidgle
rvsgipasklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivff
geplpqrfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawh
prsrdvaqlgdvvhgveslvellgwteemrdlvqretgkldgpdk

    Sequence, based on observed residues (ATOM records): (download) 
    >4jsrA (A:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgkl