PDB entry 4jql
View 4jql on RCSB PDB site
Description: Synthesis of Benzoquinone-Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid
Class: chaperone/Inhibitor
Keywords: Inhibitor design, Hsp90, nucleotide binding domain, chaperone, Geldanamycin, Cytosole, chaperone-Inhibitor complex
Deposited on
2013-03-20, released
2013-04-10
The last revision prior to the SCOPe 2.07 freeze date was dated
2013-05-22, with a file datestamp of
2013-05-17.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: 0.169
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Heat shock protein HSP 90-alpha
Species: Homo sapiens [TaxId:9606]
Gene: HSP90AA1, HSP90A, HSPC1, HSPCA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d4jqla_ - Heterogens: VJ6, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4jqlA (A:)
mgsshhhhhhssglvprgshmdqpmeeeevetfafqaeiaqlmsliintfysnkeiflre
lisnssdaldkiryesltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnl
gtiaksgtkafmealqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessag
gsftvrtdtgepmgrgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerd
kevsddeae
Sequence, based on observed residues (ATOM records): (download)
>4jqlA (A:)
qpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpsk
ldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadis
migqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilh
lkedqteyleerrikeivkkhsqfigypitlfvek