PDB entry 4jpz

View 4jpz on RCSB PDB site
Description: Voltage-gated sodium channel 1.2 C-terminal domain in complex with FGF13U and Ca2+/calmodulin
Class: transport protein
Keywords: EF hand and IQ motif, ion channel, membrane, TRANSPORT PROTEIN
Deposited on 2013-03-19, released 2014-04-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor 13
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF13, FHF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4jpza_
  • Chain 'B':
    Compound: Sodium channel protein type 2 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN2A, NAC2, SCN2A1, SCN2A2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4jpzc_
  • Chain 'E':
    Compound: Fibroblast growth factor 13
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF13, FHF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4jpze_
  • Chain 'H':
    Compound: Sodium channel protein type 2 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN2A, NAC2, SCN2A1, SCN2A2
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2, CAM3, CAMC, CAMIII
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4jpzi_
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jpzA (A:)
mallrksysepqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvva
iqgvqtklylamnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylgl
nkegeimkgnhvkknkpaahflpkplkvamykepslhdltefsrsgsgtptksrsvsgvl
nggksmshnest

    Sequence, based on observed residues (ATOM records): (download) 
    >4jpzA (A:)
pqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvvaiqgvqtklyl
amnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylglnkegeimkgn
hvkknkpaahflpkplkvamykepslhd

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4jpzC (C:)
madqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadg
ngtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltde
evdemireadidgdgqvnyeefvqmmtak

    Sequence, based on observed residues (ATOM records): (download) 
    >4jpzC (C:)
eeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtidf
pefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdemi
readidgdgqvnyeefvqmmtak

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4jpzE (E:)
mallrksysepqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvva
iqgvqtklylamnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylgl
nkegeimkgnhvkknkpaahflpkplkvamykepslhdltefsrsgsgtptksrsvsgvl
nggksmshnest

    Sequence, based on observed residues (ATOM records): (download) 
    >4jpzE (E:)
pqlkgivtklysrqgyhlqlqadgtidgtkdedstytlfnlipvglrvvaiqgvqtklyl
amnsegylytselftpeckfkesvfenyyvtyssmiyrqqqsgrgwylglnkegeimkgn
hvkknkpaahflpkplkvamykepslhd

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4jpzI (I:)
madqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadg
ngtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltde
evdemireadidgdgqvnyeefvqmmtak

    Sequence, based on observed residues (ATOM records): (download) 
    >4jpzI (I:)
eeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtidf
pefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdemi
readidgdgqvnyeefvqmmtak