PDB entry 4jkc

View 4jkc on RCSB PDB site
Description: Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion
Class: RNA binding protein
Keywords: metalloprotein, conformational change, RNA BINDING PROTEIN
Deposited on 2013-03-09, released 2013-05-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-06-26, with a file datestamp of 2013-06-21.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.13
AEROSPACI score: 0.71 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pre-mRNA-processing-splicing factor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: PRP8, PRPC8, PRPF8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P2Q9 (Start-221)
      • engineered mutation (31)
    Domains in SCOPe 2.07: d4jkca_
  • Chain 'B':
    Compound: Pre-mRNA-processing-splicing factor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: PRP8, PRPC8, PRPF8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P2Q9 (Start-221)
      • engineered mutation (31)
    Domains in SCOPe 2.07: d4jkcb_
  • Heterogens: CL, GOL, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jkcA (A:)
gelfsnqiiwfvddtnvyrvtihktfegnltekpingaififnprtgqlflkiihtsvwa
gqkrlgqlakwktaeevaalirslpveeqpkqiivtrkgmldplevhlldfpnivikgse
lqlpfqaclkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnnd
rakvilkpdkttitephhiwptltdeewikvevqlkdlilad

    Sequence, based on observed residues (ATOM records): (download) 
    >4jkcA (A:)
lfsnqiiwfvddtnvyrvtihktfegnltekpingaififnprtgqlflkiihtsvwagq
krlgqlakwktaeevaalirslpveeqpkqiivtrkgmldplevhlldfpnivikgselq
lpfqaclkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnndra
kvilkpdkttitephhiwptltdeewikvevqlkdlilad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jkcB (B:)
gelfsnqiiwfvddtnvyrvtihktfegnltekpingaififnprtgqlflkiihtsvwa
gqkrlgqlakwktaeevaalirslpveeqpkqiivtrkgmldplevhlldfpnivikgse
lqlpfqaclkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnnd
rakvilkpdkttitephhiwptltdeewikvevqlkdlilad

    Sequence, based on observed residues (ATOM records): (download) 
    >4jkcB (B:)
elfsnqiiwfvddtnvyrvtihkekpingaififnprtgqlflkiihtsvwagqkrlgql
akwktaeevaalirslpveeqpkqiivtrkgmldplevhlldfpnivikgselqlpfqac
lkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnndrakvilkp
dkttitephhiwptltdeewikvevqlkdlilad