PDB entry 4jk8

View 4jk8 on RCSB PDB site
Description: Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion
Class: RNA binding protein
Keywords: metalloprotein, conformational change, RNA BINDING PROTEIN
Deposited on 2013-03-09, released 2013-05-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-06-26, with a file datestamp of 2013-06-21.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: 0.141
AEROSPACI score: 0.9 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pre-mRNA-processing-splicing factor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: PRP8, PRPC8, PRPF8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P2Q9 (Start-221)
      • engineered mutation (96)
    Domains in SCOPe 2.07: d4jk8a_
  • Chain 'B':
    Compound: Pre-mRNA-processing-splicing factor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: PRP8, PRPC8, PRPF8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P2Q9 (Start-221)
      • engineered mutation (96)
    Domains in SCOPe 2.07: d4jk8b_
  • Heterogens: GOL, CL, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jk8A (A:)
gelfsnqiiwfvddtnvyrvtihktfegnlttkpingaififnprtgqlflkiihtsvwa
gqkrlgqlakwktaeevaalirslpveeqpkqiivtakgmldplevhlldfpnivikgse
lqlpfqaclkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnnd
rakvilkpdkttitephhiwptltdeewikvevqlkdlilad

    Sequence, based on observed residues (ATOM records): (download) 
    >4jk8A (A:)
lfsnqiiwfvddtnvyrvtihktfegnlttkpingaififnprtgqlflkiihtsvwagq
krlgqlakwktaeevaalirslpveeqpkqiivtakgmldplevhlldfpnivikgselq
lpfqaclkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnndra
kvilkpdkttitephhiwptltdeewikvevqlkdlilad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jk8B (B:)
gelfsnqiiwfvddtnvyrvtihktfegnlttkpingaififnprtgqlflkiihtsvwa
gqkrlgqlakwktaeevaalirslpveeqpkqiivtakgmldplevhlldfpnivikgse
lqlpfqaclkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnnd
rakvilkpdkttitephhiwptltdeewikvevqlkdlilad

    Sequence, based on observed residues (ATOM records): (download) 
    >4jk8B (B:)
elfsnqiiwfvddtnvyrvtihktfegnlttkpingaififnprtgqlflkiihtsvwag
qkrlgqlakwktaeevaalirslpveeqpkqiivtakgmldplevhlldfpnivikgsel
qlpfqaclkvekfgdlilkatepqmvlfnlyddwlktissytafsrlililralhvnndr
akvilkpdkttitephhiwptltdeewikvevqlkdlilad