PDB entry 4ji9

View 4ji9 on RCSB PDB site
Description: JAK2 kinase (JH1 domain) in complex with TG101209
Class: transferase/transferase inhibitor
Keywords: protein kinase, phospho-transfer catalyst, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-03-05, released 2013-08-07
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-08-21, with a file datestamp of 2013-08-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.203
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ji9a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ji9b_
  • Heterogens: 1M3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ji9A (A:)
sgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehl
rdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhik
llqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvke
pgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgq
mivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >4ji9A (A:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknng
rlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ji9B (B:)
sgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehl
rdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhik
llqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvke
pgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgq
mivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >4ji9B (B:)
rdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfere
ieilkslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqick
gmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwya
peslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliell
knngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag