PDB entry 4jef
View 4jef on RCSB PDB site
Description: Crystal structure of human thymidylate synthase Y202A in inactive conformation.
Class: transferase
Keywords: Inactive form of human thymidylate synthase, hot spot residue, TRANSFERASE
Deposited on
2013-02-26, released
2014-08-20
The last revision prior to the SCOPe 2.06 freeze date was dated
2015-05-06, with a file datestamp of
2015-05-01.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.24
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Thymidylate synthase
Species: Homo sapiens [TaxId:9606]
Gene: TYMS, TS, OK/SW-cl.29
Database cross-references and differences (RAF-indexed):
- Uniprot P04818 (0-285)
- engineered mutation (176)
Domains in SCOPe 2.06: d4jefa_ - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4jefA (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfavvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmem
Sequence, based on observed residues (ATOM records): (download)
>4jefA (A:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelslgpvygfqwrhfysgqgvdqlqrvidtiktnpddrriimcawn
prdlplmalppchalcqfavvnselscqlyqrsgdmglgvpfniasyalltymiahitgl
kpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynp
hptikmem