PDB entry 4jef

View 4jef on RCSB PDB site
Description: Crystal structure of human thymidylate synthase Y202A in inactive conformation.
Class: transferase
Keywords: Inactive form of human thymidylate synthase, hot spot residue, TRANSFERASE
Deposited on 2013-02-26, released 2014-08-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-05-06, with a file datestamp of 2015-05-01.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818 (0-285)
      • engineered mutation (176)
    Domains in SCOPe 2.06: d4jefa_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4jefA (A:)
    pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
    eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
    yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfavvn
    selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
    kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmem
    

    Sequence, based on observed residues (ATOM records): (download)
    >4jefA (A:)
    pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
    eellwfikgstnakelslgpvygfqwrhfysgqgvdqlqrvidtiktnpddrriimcawn
    prdlplmalppchalcqfavvnselscqlyqrsgdmglgvpfniasyalltymiahitgl
    kpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynp
    hptikmem