PDB entry 4jbx

View 4jbx on RCSB PDB site
Description: Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with SK-78
Class: transferase
Keywords: DNA synthesis, PET imaging TRACER, ATP binding, nucleotide binding, TRANSFERASE
Deposited on 2013-02-20, released 2013-03-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-10-02, with a file datestamp of 2013-09-27.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.175
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1 [TaxId:10299]
    Gene: TK, TK (UL23), UL23
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jbxa_
  • Chain 'B':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1 [TaxId:10299]
    Gene: TK, TK (UL23), UL23
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4jbxb_
  • Heterogens: SK7, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jbxA (A:)
kmptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttq
hrldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrh
piaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpg
erldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphi
gdtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlt
sgmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >4jbxA (A:)
kmptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttq
hrldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeapppaltlifdrhpiaal
lcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerldl
amlaairrvygllantvrylqcggswredwgqlsgprphigdtlftlfrapellapngdl
ynvfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdl
artfaremge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jbxB (B:)
kmptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttq
hrldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrh
piaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpg
erldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphi
gdtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlt
sgmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >4jbxB (B:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeaapppaltlifdrhpiaal
lcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrdlamlaair
rvygllantvrylqcggswredwgqlsgpqsnagprphigdtlftlfrapellapngdly
nvfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdla
rtfaremge