PDB entry 4jbs

View 4jbs on RCSB PDB site
Description: Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 in complex with PHOSPHINIC PSEUDOTRIPEPTIDE inhibitor.
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Thermolysin-like catalytic domain, Hydrolase, Aminopeptidase, Zinc binding, Endoplasmic Reticulum, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2013-02-20, released 2013-12-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.79 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • expression tag (960)
    Domains in SCOPe 2.07: d4jbsa1, d4jbsa2, d4jbsa3, d4jbsa4, d4jbsa5
  • Chain 'B':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • expression tag (960)
    Domains in SCOPe 2.07: d4jbsb1, d4jbsb2, d4jbsb3, d4jbsb4, d4jbsb5
  • Heterogens: NAG, ZN, P52, IMD, MAN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jbsA (A:)
mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4jbsA (A:)
pvatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhsk
dleitnatlqseeymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgf
egfykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnm
pkvktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqt
hyalqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpkts
sasdklwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddy
flnvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqk
giiqylkkfsyrnaknddlwsslsnslgenaevkemmttwtlqkgipllvvkqdgcslrl
qqerflqgqerylwhipltystsssnvihrhilksktdtldlpektswvkfnvdsngyyi
vhyeghgwdqlitqlnqnhtllrpkdrvglihdvfqlvgagrltldkaldmtyylqhets
spalleglsylesfyhmmdrrnisdisenlkryllqyfkpvidrqswsdkgsvwdrmlrs
allklacdlnhapciqkaaelfsqwmessgklniptdvlkivysvgaqttagwnylleqy
elsmssaeqnkilyalstskhqekllklielgmegkviktqnlaallhaiarrpkgqqla
wdfvrenwthllkkfdlgsydirmiisgttahfsskdklqevklffesleaqgshldifq
tvletitknikwleknlptlrtwlmvntr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4jbsB (B:)
mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4jbsB (B:)
vatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskd
leitnatlqsepgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfyk
styrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvkt
ielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyalq
aslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasdk
lwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddyflnvc
fevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiqy
lkkfsyrnaknddlwsslsnsaevkemmttwtlqkgiplldgcslrlqqerflqgveryl
whiplttsssnvihrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitql
nqnhtllrpkdrvglihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfy
hmmdrrnisdisenlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapci
qkaaelfsqwmessgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilya
lstskhqekllklielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkf
dlgsydirmiisgttahfsskdklqevklffesleaqgshldifqtvletitknikwlek
nlptlrtwlmvntr