PDB entry 4j96
View 4j96 on RCSB PDB site
Description: Crystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.
Class: transferase
Keywords: Kinase Domain Fold Consisting of N- and C-lobes, Receptor Tyrosine Kinase, ATP Binding, TRANSFERASE
Deposited on
2013-02-15, released
2013-08-07
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-08-21, with a file datestamp of
2013-08-16.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.178
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Fibroblast growth factor receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: BEK, FGFR2, KGFR, KSAM
Database cross-references and differences (RAF-indexed):
- Uniprot P21802
- engineered mutation (46)
- engineered mutation (214)
Domains in SCOPe 2.06: d4j96a_ - Chain 'B':
Compound: Fibroblast growth factor receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: BEK, FGFR2, KGFR, KSAM
Database cross-references and differences (RAF-indexed):
- Uniprot P21802
- engineered mutation (46)
- engineered mutation (214)
Domains in SCOPe 2.06: d4j96b_ - Heterogens: SO4, FLC, ACP, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4j96A (A:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmkiadfglardinnidyykmttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee
Sequence, based on observed residues (ATOM records): (download)
>4j96A (A:)
agvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlk
ddatekdlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarr
ppsydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmkiad
fglardinnidyykmttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlggspy
pgipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldriltlt
tn
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4j96B (B:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmkiadfglardinnidyykmttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee
Sequence, based on observed residues (ATOM records): (download)
>4j96B (B:)
gvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgidkdkpkeavtvavkmlkd
datekdlsdlvsememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrp
pgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcihrdlaarnvlvtennvmk
iadfglardinnidyykmttngrlpvkwmapealfdrvythqsdvwsfgvlmweiftlgg
spypgipveelfkllkeghrmdkpanctnelymmmrdcwhavpsqrptfkqlvedldril
tlttn