PDB entry 4j7b

View 4j7b on RCSB PDB site
Description: Crystal structure of polo-like kinase 1
Class: transferase
Keywords: First complex structure of KD and PBD domain, regulator of mitosis, phosphorylated target protein, TRANSFERASE
Deposited on 2013-02-13, released 2013-07-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.208
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Polo-like kinase
    Species: Danio rerio [TaxId:7955]
    Gene: PLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DRK7 (2-End)
      • engineered mutation (146)
    Domains in SCOPe 2.06: d4j7ba_
  • Chain 'B':
    Compound: Polo-like kinase
    Species: Danio rerio [TaxId:7955]
    Gene: PLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DRK7
      • engineered mutation (25)
    Domains in SCOPe 2.06: d4j7bb1, d4j7bb2
  • Chain 'C':
    Compound: 205 kDa microtubule-associated protein
    Species: Drosophila melanogaster [TaxId:7227]
    Gene: Map205, CG1483
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Polo-like kinase
    Species: Danio rerio [TaxId:7955]
    Gene: PLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DRK7
      • engineered mutation (146)
    Domains in SCOPe 2.06: d4j7bd_
  • Chain 'E':
    Compound: Polo-like kinase
    Species: Danio rerio [TaxId:7955]
    Gene: PLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6DRK7
      • engineered mutation (25)
    Domains in SCOPe 2.06: d4j7be1, d4j7be2
  • Chain 'F':
    Compound: 205 kDa microtubule-associated protein
    Species: Drosophila melanogaster [TaxId:7227]
    Gene: Map205, CG1483
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4j7bA (A:)
mgpksaplkeipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvpksml
lkphqkekmsteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrrkavt
epearyfmrqtiqgvqylhnnrvihrnlklgnlflnddmdvkigdfglatkiefdgfrkk
tlcgtpnyiapevlckkghsfevdiwslgcilytllvgkppfetsclketyirikkneys
vprhinpvasalirrmlhadptlrpsvaelltdefftsgyapmrlptscltvpprfs

    Sequence, based on observed residues (ATOM records): (download) 
    >4j7bA (A:)
pksaplkeipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvpksmllk
phqkekmsteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrrkavtep
earyfmrqtiqgvqylhnnrvihrnlklgnlflnddmdvkigdfglatkicgtpnyiape
vlckkghsfevdiwslgcilytllvgkppfetsclketyirikkneysvprhinpvasal
irrmlhadptlrpsvaelltdefftsgyapmrlptscltvpprf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4j7bB (B:)
mqpdthltdmlqqlavvnaakpsdrgfirqeeaedpacipvfwiskwvdysdkyglgyql
sdnsvgvlfndstrlimcadgdslqyidrnslesylsvrsypsalskkitllkyfrnyms
ehllkaganitpregdeltrlpylrhwfrtksaivlhlsngtvqinffqdhtklilcplm
gavtyinekrefytykmtlieefgcckelasrlryarnmveklmackssttaatsar

    Sequence, based on observed residues (ATOM records): (download) 
    >4j7bB (B:)
thltdmlqqlavvnaakpsdrgfirqeeaedpacipvfwiskwvdysdkyglgyqlsdns
vgvlfndstrlimcadgdslqyidrnslesylsvrsypsalskkitllkyfrnymsepre
gdeltrlpylrhwfrtksaivlhlsngtvqinffqdhtklilcplmgavtyinekrefyt
ykmtlieefgcckelasrlryarnmveklmack

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4j7bD (D:)
mgpksaplkeipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvpksml
lkphqkekmsteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrrkavt
epearyfmrqtiqgvqylhnnrvihrnlklgnlflnddmdvkigdfglatkiefdgfrkk
tlcgtpnyiapevlckkghsfevdiwslgcilytllvgkppfetsclketyirikkneys
vprhinpvasalirrmlhadptlrpsvaelltdefftsgyapmrlptscltvpprfs

    Sequence, based on observed residues (ATOM records): (download) 
    >4j7bD (D:)
saplkeipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvpksmllkph
qkekmsteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrrkavtepea
ryfmrqtiqgvqylhnnrvihrnlklgnlflnddmdvkigdfglatkigtpnyiapevlc
kkghsfevdiwslgcilytllvgkppfetsclketyirikkneysvprhinpvasalirr
mlhadptlrpsvaelltdefftsgyapmrlptscltvpprf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4j7bE (E:)
mqpdthltdmlqqlavvnaakpsdrgfirqeeaedpacipvfwiskwvdysdkyglgyql
sdnsvgvlfndstrlimcadgdslqyidrnslesylsvrsypsalskkitllkyfrnyms
ehllkaganitpregdeltrlpylrhwfrtksaivlhlsngtvqinffqdhtklilcplm
gavtyinekrefytykmtlieefgcckelasrlryarnmveklmackssttaatsar

    Sequence, based on observed residues (ATOM records): (download) 
    >4j7bE (E:)
thltdmlqqlavvnaakpsdrgfirqeeaedpacipvfwiskwvdysdkyglgyqlsdns
vgvlfndstrlimcadgdslqyidrnslesylsvrsypsalskkitllkyfrnymsepre
gdeltrlpylrhwfrtksaivlhlsngtvqinffqdhtklilcplmgavtyinekrefyt
ykmtlieefgcckelasrlryarnmveklmack

  • Chain 'F':
    No sequence available.