PDB entry 4j0r

View 4j0r on RCSB PDB site
Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand
Class: signaling protein
Keywords: BRD4, Bromodomain containing protein 4, CAP, HUNK1, MCAP, Mitotic chromosome associated protein, Isoxazole, Structural Genomics Consortium, SGC, SIGNALING PROTEIN
Deposited on 2013-01-31, released 2013-02-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-05-29, with a file datestamp of 2013-05-24.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: 0.16
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (2-126)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d4j0ra1, d4j0ra2
  • Heterogens: EDO, 1H2, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4j0rA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
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