PDB entry 4iz7

View 4iz7 on RCSB PDB site
Description: Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain
Class: Transferase
Keywords: MAP Kinase, Death effector domain, Transferase
Deposited on 2013-01-29, released 2013-04-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-04-24, with a file datestamp of 2013-04-19.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.187
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4iz7a_
  • Chain 'B':
    Compound: Astrocytic phosphoprotein PEA-15
    Species: Cricetulus griseus [TaxId:10029]
    Gene: PEA15
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Z297 (1-End)
      • expression tag (0)
  • Chain 'C':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4iz7c_
  • Heterogens: NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4iz7A (A:)
    gpggagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqty
    cqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsnd
    hicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfl
    teyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgil
    gspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkriev
    eqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs
    

    Sequence, based on observed residues (ATOM records): (download)
    >4iz7A (A:)
    pemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlr
    eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
    yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhteyvatrwyrap
    eimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlncii
    nlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqy
    ydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4iz7C (C:)
    gpggagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqty
    cqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsnd
    hicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfl
    teyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgil
    gspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkriev
    eqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs
    

    Sequence, based on observed residues (ATOM records): (download)
    >4iz7C (C:)
    pemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlr
    eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
    yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpeyvatrwyrapeim
    lnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlk
    arnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydp
    sdepiaeapfkfdmelddlpkeklkelifeetarfqpgyr