PDB entry 4iz5

View 4iz5 on RCSB PDB site
Description: Structure of the complex between ERK2 phosphomimetic mutant and PEA-15
Class: Transferase
Keywords: MAP Kinase, Death Effector Domain, Transferase
Deposited on 2013-01-29, released 2013-04-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-04-24, with a file datestamp of 2013-04-19.
Experiment type: XRAY
Resolution: 3.19 Å
R-factor: 0.245
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28482
      • engineered mutation (180)
    Domains in SCOPe 2.04: d4iz5a_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28482
      • engineered mutation (180)
    Domains in SCOPe 2.04: d4iz5b_
  • Chain 'C':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28482
      • engineered mutation (180)
    Domains in SCOPe 2.04: d4iz5c_
  • Chain 'D':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28482
      • engineered mutation (180)
    Domains in SCOPe 2.04: d4iz5d_
  • Chain 'E':
    Compound: Astrocytic phosphoprotein PEA-15
    Species: Homo sapiens [TaxId:9606]
    Gene: PEA15
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Astrocytic phosphoprotein PEA-15
    Species: Homo sapiens [TaxId:9606]
    Gene: PEA15
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Astrocytic phosphoprotein PEA-15
    Species: Homo sapiens [TaxId:9606]
    Gene: PEA15
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Astrocytic phosphoprotein PEA-15
    Species: Homo sapiens [TaxId:9606]
    Gene: PEA15
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ADP, SO4

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4iz5A (A:)
gpggagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqty
cqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsnd
hicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfl
eeyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgil
gspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkriev
eqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4iz5A (A:)
pemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlr
eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfleeyvat
rwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqe
dlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalah
pyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4iz5B (B:)
gpggagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqty
cqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsnd
hicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfl
eeyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgil
gspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkriev
eqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4iz5B (B:)
pemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlr
eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfleeyvat
rwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqe
dlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalah
pyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4iz5C (C:)
gpggagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqty
cqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsnd
hicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfl
eeyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgil
gspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkriev
eqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4iz5C (C:)
pemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlr
eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfleeyvat
rwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqe
dlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalah
pyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4iz5D (D:)
gpggagpemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqty
cqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsnd
hicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfl
eeyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgil
gspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkriev
eqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4iz5D (D:)
pemvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlr
eikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfl
yqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgfleeyvat
rwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqe
dlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalah
pyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpg

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.