PDB entry 4iw5

View 4iw5 on RCSB PDB site
Description: Thymidylate synthase ternary complex with dUMP and CB3717
Class: transferase
Keywords: alpha/beta protein, methyltransferase, methylenetetrahydrofolate, antifolate, TRANSFERASE
Deposited on 2013-01-23, released 2013-02-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-05-22, with a file datestamp of 2013-05-17.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.133
AEROSPACI score: 0.78 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Escherichia coli [TaxId:83333]
    Gene: b2827, JW2795, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4iw5a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Escherichia coli [TaxId:83333]
    Gene: b2827, JW2795, thyA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4iw5b_
  • Heterogens: UMC, CB3, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4iw5A (A:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4iw5B (B:)
mkqylelmqkvldegtqkndrtgtgtlsifghqmrfnlqdgfplvttkrchlrsiihell
wflqgdtniaylhennvtiwdewadengdlgpvygkqwrawptpdgrhidqittvlnqlk
ndpdsrriivsawnvgeldkmalapchaffqfyvadgklscqlyqrscdvflglpfnias
yallvhmmaqqcdlevgdfvwtggdthlysnhmdqthlqlsreprplpkliikrkpesif
dyrfedfeiegydphpgikapvai