PDB entry 4iva

View 4iva on RCSB PDB site
Description: JAK2 kinase (JH1 domain) in complex with the inhibitor TRANS-4-[(8AS)-2-[(1R)-1-HYDROXYETHYL]IMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-1(8AH)-YL]CYCLOHEXANECARBONITRILE
Class: transferase/transferase inhibitor
Keywords: protein kinase, phosphotransfer, transferase-transferase inhibitor complex
Deposited on 2013-01-22, released 2013-05-22
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-07-03, with a file datestamp of 2013-06-28.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.176
AEROSPACI score: 0.64 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ivaa_
  • Heterogens: 1J5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ivaA (A:)
sgafedrdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehl
rdfereieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhik
llqytsqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvke
pgespifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgq
mivfhliellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >4ivaA (A:)
ptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereie
ilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsqi
ckgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifw
yapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhlie
llknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag