PDB entry 4itx

View 4itx on RCSB PDB site
Description: P113S mutant of E. coli Cystathionine beta-lyase MetC inhibited by reaction with d-ALA-P
Class: lyase
Keywords: Cystathionine beta-lyase, LYASE
Deposited on 2013-01-19, released 2014-12-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-12-24, with a file datestamp of 2014-12-19.
Experiment type: XRAY
Resolution: 1.61 Å
R-factor: 0.163
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystathionine beta-lyase MetC
    Species: Escherichia coli [TaxId:83333]
    Gene: b3008, JW2975, metC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06721 (Start-394)
      • engineered mutation (112)
    Domains in SCOPe 2.06: d4itxa_
  • Chain 'B':
    Compound: Cystathionine beta-lyase MetC
    Species: Escherichia coli [TaxId:83333]
    Gene: b3008, JW2975, metC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06721 (Start-394)
      • engineered mutation (112)
    Domains in SCOPe 2.06: d4itxb_
  • Heterogens: IN5, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4itxA (A:)
madkkldtqlvnagrskkytlgavnsviqrasslvfdsveakkhatrnrangelfygrrg
tlthfslqqamceleggagcvlfpcgaaavansilafieqgdhvlmtntayessqdfcsk
ilsklgvttswfdpligadivkhlqpntkivflespgsitmevhdvpaivaavrsvvpda
iimidntwaagvlfkaldfgidvsiqaatkylvghsdamigtavcnarcweqlrenaylm
gqmvdadtayitsrglrtlgvrlrqhhesslkvaewlaehpqvarvnhpalpgskghefw
krdftgssglfsfvlkkklnneelanyldnfslfsmayswggyeslilanqpehiaairp
qgeidfsgtlirlhigledvddliadldagfariv

    Sequence, based on observed residues (ATOM records): (download) 
    >4itxA (A:)
kldtqlvnagrskkytlgavnsviqrasslvfdsveakkhatrnrangelfygrrgtlth
fslqqamceleggagcvlfpcgaaavansilafieqgdhvlmtntayessqdfcskilsk
lgvttswfdpligadivkhlqpntkivflespgsitmevhdvpaivaavrsvvpdaiimi
dntwaagvlfkaldfgidvsiqaatkylvghsdamigtavcnarcweqlrenaylmgqmv
dadtayitsrglrtlgvrlrqhhesslkvaewlaehpqvarvnhpalpgskghefwkrdf
tgssglfsfvlkkklnneelanyldnfslfsmayswggyeslilanqpehiaairpqgei
dfsgtlirlhigledvddliadldagfariv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4itxB (B:)
madkkldtqlvnagrskkytlgavnsviqrasslvfdsveakkhatrnrangelfygrrg
tlthfslqqamceleggagcvlfpcgaaavansilafieqgdhvlmtntayessqdfcsk
ilsklgvttswfdpligadivkhlqpntkivflespgsitmevhdvpaivaavrsvvpda
iimidntwaagvlfkaldfgidvsiqaatkylvghsdamigtavcnarcweqlrenaylm
gqmvdadtayitsrglrtlgvrlrqhhesslkvaewlaehpqvarvnhpalpgskghefw
krdftgssglfsfvlkkklnneelanyldnfslfsmayswggyeslilanqpehiaairp
qgeidfsgtlirlhigledvddliadldagfariv

    Sequence, based on observed residues (ATOM records): (download) 
    >4itxB (B:)
kkldtqlvnagrskkytlgavnsviqrasslvfdsveakkhatrnrangelfygrrgtlt
hfslqqamceleggagcvlfpcgaaavansilafieqgdhvlmtntayessqdfcskils
klgvttswfdpligadivkhlqpntkivflespgsitmevhdvpaivaavrsvvpdaiim
idntwaagvlfkaldfgidvsiqaatkylvghsdamigtavcnarcweqlrenaylmgqm
vdadtayitsrglrtlgvrlrqhhesslkvaewlaehpqvarvnhpalpgskghefwkrd
ftgssglfsfvlkkklnneelanyldnfslfsmayswggyeslilanqpehiaairpqge
idfsgtlirlhigledvddliadldagfariv