PDB entry 4isi
View 4isi on RCSB PDB site
Description: Structure of FACTOR VIIA in complex with the inhibitor (6S)-N-(4-CARBAMIMIDOYLBENZYL)-1-CHLORO-3-(CYCLOBUTYLAMINO)-8,8-DIETHYL-4-OXO-4,6,7,8-TETRAHYDROPYRROLO[1,2-A]PYRAZINE-6-CARBOXAMIDE
Class: HYDROLASE/Hydrolase Inhibitor
Keywords: GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE-Hydrolase Inhibitor complex
Deposited on
2013-01-16, released
2013-02-27
The last revision prior to the SCOPe 2.02 freeze date was dated
2013-03-06, with a file datestamp of
2013-03-01.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: 0.21
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Factor VII heavy chain
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d4isih_ - Chain 'L':
Compound: Factor VII light chain
Species: Homo sapiens [TaxId:9606]
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d4isil_ - Heterogens: 1GG, CA, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>4isiH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>4isiL (L:)
icvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr