PDB entry 4ish

View 4ish on RCSB PDB site
Description: Structure of FACTOR VIIA in complex with the inhibitor BMS-593214 also known as 2'-[(6R,6AR,11BR)-2-CARBAMIMIDOYL-6,6A,7,11B-TETRAHYDRO-5H-INDENO[2,1-C]QUINOLIN-6-YL]-5'-HYDROXY-4'-METHOXYBIPHENYL-4-CARBOXYLIC ACID
Class: HYDROLASE/Hydrolase Inhibitor
Keywords: GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE-Hydrolase Inhibitor complex
Deposited on 2013-01-16, released 2013-03-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-04-03, with a file datestamp of 2013-03-29.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: 0.196
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'H':
  Compound: Factor VII heavy chain
  Species: Homo sapiens [TaxId:9606]
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-253)
  Domains in SCOPe 2.08: d4ishh_
• Chain 'L':
  Compound: Factor VII light chain
  Species: Homo sapiens [TaxId:9606]
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-54)
  Domains in SCOPe 2.08: d4ishl_
• Heterogens: 1GE, CA, HOH

PDB Chain Sequences:

• Chain 'H':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4ishH (H:)
  ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
  lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
  lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
  sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
  seprpgvllrapfp
  

  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4ishL (L:)
  icvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr