PDB entry 4iqq

View 4iqq on RCSB PDB site
Description: Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP and Tomudex
Class: Transferase/Transferase Inhibitor
Keywords: METHYLTRANSFERASE, INHIBITOR, ANTIFOLATE, PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, Transferase-Transferase Inhibitor complex
Deposited on 2013-01-13, released 2014-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-01-22, with a file datestamp of 2014-01-17.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.222
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Caenorhabditis elegans [TaxId:6239]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4iqqa_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Caenorhabditis elegans [TaxId:6239]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4iqqb_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Caenorhabditis elegans [TaxId:6239]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4iqqc_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Caenorhabditis elegans [TaxId:6239]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4iqqd_
  • Heterogens: UMP, D16, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4iqqA (A:)
mevmnkeniiadapsdvvktvqqqvhlnqdeykylkqveqilregtrrddrtgtgtisif
gmqskyclrngtipllttkrvywkgvleellwfisgstdgkllmeknvkiwekngdrafl
dnlgftsreegdlgpvygfqwrhfgakyvdchtdysgqgvdqlaevirqikeqpdsrrii
msawnpsdlgqmvlppchtmcqfyvdngelscqlyqrsgdmglgvpfnlasygllthmia
kvcglkpgtlvhtlgdahvysnhvdalkiqldrepyafpkirftrdvasiddftsdmial
ddykchpkipmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >4iqqA (A:)
qvhlnqdeykylkqveqilregtrrddrtgtgtisifgmqskyclrngtipllttkrvyw
kgvleellwfisgstdgkllmeknvkiwekngdrafldnlgftsreegdlgpvygfqwrh
fgakyvdchtdysgqgvdqlaevirqikeqpdsrriimsawnpsdlgqmvlppchtmcqf
yvdngelscqlyqrsgdmglgvpfnlasygllthmiakvcglkpgtlvhtlgdahvysnh
vdalkiqldrepyafpkirftrdvasiddftsdmialddykchpkipmd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4iqqB (B:)
mevmnkeniiadapsdvvktvqqqvhlnqdeykylkqveqilregtrrddrtgtgtisif
gmqskyclrngtipllttkrvywkgvleellwfisgstdgkllmeknvkiwekngdrafl
dnlgftsreegdlgpvygfqwrhfgakyvdchtdysgqgvdqlaevirqikeqpdsrrii
msawnpsdlgqmvlppchtmcqfyvdngelscqlyqrsgdmglgvpfnlasygllthmia
kvcglkpgtlvhtlgdahvysnhvdalkiqldrepyafpkirftrdvasiddftsdmial
ddykchpkipmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >4iqqB (B:)
qvhlnqdeykylkqveqilregtrrddrtgtgtisifgmqskyclrngtipllttkrvyw
kgvleellwfisgstdgkllmeknvkiwekngdrafldnlgftsreegdlgpvygfqwrh
fgakyvdchtdysgqgvdqlaevirqikeqpdsrriimsawnpsdlgqmvlppchtmcqf
yvdngelscqlyqrsgdmglgvpfnlasygllthmiakvcglkpgtlvhtlgdahvysnh
vdalkiqldrepyafpkirftrdvasiddftsdmialddykchpkipmd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4iqqC (C:)
mevmnkeniiadapsdvvktvqqqvhlnqdeykylkqveqilregtrrddrtgtgtisif
gmqskyclrngtipllttkrvywkgvleellwfisgstdgkllmeknvkiwekngdrafl
dnlgftsreegdlgpvygfqwrhfgakyvdchtdysgqgvdqlaevirqikeqpdsrrii
msawnpsdlgqmvlppchtmcqfyvdngelscqlyqrsgdmglgvpfnlasygllthmia
kvcglkpgtlvhtlgdahvysnhvdalkiqldrepyafpkirftrdvasiddftsdmial
ddykchpkipmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >4iqqC (C:)
qvhlnqdeykylkqveqilregtrrddrtgtgtisifgmqskyclrngtipllttkrvyw
kgvleellwfisgstdgkllmeknvkiwekngdrafldnlgftsreegdlgpvygfqwrh
fgakyvdchtdysgqgvdqlaevirqikeqpdsrriimsawnpsdlgqmvlppchtmcqf
yvdngelscqlyqrsgdmglgvpfnlasygllthmiakvcglkpgtlvhtlgdahvysnh
vdalkiqldrepyafpkirftrdvasiddftsdmialddykchpkipm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4iqqD (D:)
mevmnkeniiadapsdvvktvqqqvhlnqdeykylkqveqilregtrrddrtgtgtisif
gmqskyclrngtipllttkrvywkgvleellwfisgstdgkllmeknvkiwekngdrafl
dnlgftsreegdlgpvygfqwrhfgakyvdchtdysgqgvdqlaevirqikeqpdsrrii
msawnpsdlgqmvlppchtmcqfyvdngelscqlyqrsgdmglgvpfnlasygllthmia
kvcglkpgtlvhtlgdahvysnhvdalkiqldrepyafpkirftrdvasiddftsdmial
ddykchpkipmdmav

    Sequence, based on observed residues (ATOM records): (download) 
    >4iqqD (D:)
vhlnqdeykylkqveqilregtrrddrtgtgtisifgmqskyclrngtipllttkrvywk
gvleellwfisgstdgkllmeknvkiwekngdrafldnlgftsreegdlgpvygfqwrhf
gakyvdchtdysgqgvdqlaevirqikeqpdsrriimsawnpsdlgqmvlppchtmcqfy
vdngelscqlyqrsgdmglgvpfnlasygllthmiakvcglkpgtlvhtlgdahvysnhv
dalkiqldrepyafpkirftrdvasiddftsdmialddykchpkipmd