PDB entry 4igf

View 4igf on RCSB PDB site
Description: Crystal structure of Plasmodium falciparum FabI complexed with NAD and inhibitor 3-(4-Chloro-2-hydroxyphenoxy)-7-hydroxy-2H-chromen-2-one
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Reductase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2012-12-17, released 2013-11-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: enoyl-acyl carrier reductase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PfENR, PFF0730c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4igfa_
  • Chain 'B':
    Compound: enoyl-acyl carrier reductase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PfENR, PFF0730c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4igfb_
  • Heterogens: CHV, NAD, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4igfA (A:)
    mvhhhhhhnedicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkf
    dndmiidkdkkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkyg
    kinmlvhslanakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiislty
    hasqkvvpgygggmssakaalesdtrvlayhlgrnynirintisagplksraatainkln
    ntyenntnqnknrnshdvhnimnnsgekeekknsasqnytfidyaieysekyaplrqkll
    stdigsvasfllsresraitgqtiyvdnglnimflpddiyrnene
    

    Sequence, based on observed residues (ATOM records): (download)
    >4igfA (A:)
    edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
    kkmnildmlpfdasfdtandidetknnkrynmlqnytiedvanlihqkygkinmlvhsla
    nakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpgy
    gggmssakaalesdtrvlayhlgrnynirintisagplksfidyaieysekyaplrqkll
    stdigsvasfllsresraitgqtiyvdnglnimflpd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4igfB (B:)
    mvhhhhhhnedicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkf
    dndmiidkdkkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkyg
    kinmlvhslanakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiislty
    hasqkvvpgygggmssakaalesdtrvlayhlgrnynirintisagplksraatainkln
    ntyenntnqnknrnshdvhnimnnsgekeekknsasqnytfidyaieysekyaplrqkll
    stdigsvasfllsresraitgqtiyvdnglnimflpddiyrnene
    

    Sequence, based on observed residues (ATOM records): (download)
    >4igfB (B:)
    edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
    kkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhsl
    anakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpg
    ygggmssakaalesdtrvlayhlgrnynirintisagplksraatainktfidyaieyse
    kyaplrqkllstdigsvasfllsresraitgqtiyvdnglnimflpd