PDB entry 4ig9

View 4ig9 on RCSB PDB site
Description: Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 A)
Class: hydrolase
Keywords: deacetylase, HYDROLASE
Deposited on 2012-12-16, released 2013-11-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-02-05, with a file datestamp of 2014-01-31.
Experiment type: XRAY
Resolution: 2.64 Å
R-factor: 0.228
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.06: d4ig9a1, d4ig9a2
  • Chain 'B':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (6-End)
      • expression tag (4-5)
  • Chain 'C':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.06: d4ig9c1, d4ig9c2
  • Chain 'D':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (6-End)
      • expression tag (3-5)
  • Chain 'E':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (4-End)
      • expression tag (2-3)
    Domains in SCOPe 2.06: d4ig9e1, d4ig9e2
  • Chain 'F':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (6-End)
      • expression tag (1-5)
  • Chain 'G':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (4-End)
      • expression tag (3)
    Domains in SCOPe 2.06: d4ig9g1, d4ig9g2
  • Chain 'H':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (6-End)
      • expression tag (3-5)
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ig9A (A:)
gphmrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpd
lpdpqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidt
leqvagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkp
eivffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinrepl
phlhfdvellgdcdviinelchrlggeyaklccnpvklsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4ig9A (A:)
mrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpdlpd
pqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidtleq
vagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkpeiv
ffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinreplphl
hfdvellgdcdviinelchrlggeyaklc

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ig9C (C:)
gphmrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpd
lpdpqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidt
leqvagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkp
eivffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinrepl
phlhfdvellgdcdviinelchrlggeyaklccnpvklsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4ig9C (C:)
mrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpdlpd
pqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidtleq
vagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkpeiv
ffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinreplphl
hfdvellgdcdviinelchrlggeyaklc

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4ig9E (E:)
gphmrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpd
lpdpqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidt
leqvagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkp
eivffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinrepl
phlhfdvellgdcdviinelchrlggeyaklccnpvklsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4ig9E (E:)
hmrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpdlp
dpqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidtle
qvagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkpei
vffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinreplph
lhfdvellgdcdviinelchrlggeyaklc

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4ig9G (G:)
gphmrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpd
lpdpqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidt
leqvagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkp
eivffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinrepl
phlhfdvellgdcdviinelchrlggeyaklccnpvklsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4ig9G (G:)
mrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpdlpd
pqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidtleq
vagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkpeiv
ffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinreplphl
hfdvellgdcdviinelchrlggeyaklcc

  • Chain 'H':
    No sequence available.