PDB entry 4if6

View 4if6 on RCSB PDB site
Description: Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 2.25 A)
Class: hydrolase
Keywords: deacetylase, HYDROLASE
Deposited on 2012-12-14, released 2013-10-23
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-11-06, with a file datestamp of 2013-11-01.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.159
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIR2L1, SIRT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (4-280)
      • expression tag (3)
    Domains in SCOPe 2.06: d4if6a1, d4if6a2
  • Chain 'B':
    Compound: NAD-dependent protein deacetylase sirtuin-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT1, SIR2L1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96EB6 (6-End)
      • expression tag (0-5)
  • Heterogens: ZN, APR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4if6A (A:)
gphmrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpd
lpdpqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidt
leqvagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkp
eivffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinrepl
phlhfdvellgdcdviinelchrlggeyaklccnpvklsei

    Sequence, based on observed residues (ATOM records): (download) 
    >4if6A (A:)
mrkkrkdintiedavkllqeckkiivltgagvsvscgipdfrsrdgiyarlavdfpdlpd
pqamfdieyfrkdprpffkfakeiypgqfqpslchkfialsdkegkllrnytqnidtleq
vagiqriiqchgsfatasclickykvdceavrgdifnqvvprcprcpadeplaimkpeiv
ffgenlpeqfhramkydkdevdllivigsslkvrpvalipssiphevpqilinreplphl
hfdvellgdcdviinelchrlggeyaklccnpvklsei

  • Chain 'B':
    No sequence available.