PDB entry 4ibz

View 4ibz on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R
Class: DNA binding protein
Keywords: metal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, DNA binding protein
Deposited on 2012-12-09, released 2013-08-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
      • engineered mutation (190)
    Domains in SCOPe 2.07: d4ibza_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
      • engineered mutation (190)
    Domains in SCOPe 2.07: d4ibzb_
  • Chain 'C':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
      • engineered mutation (190)
    Domains in SCOPe 2.07: d4ibzc_
  • Chain 'D':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
      • engineered mutation (190)
    Domains in SCOPe 2.07: d4ibzd_
  • Heterogens: ZN, EDO, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ibzA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibzA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvc
acpgrdrrreeen

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ibzB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibzB (B:)
vpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgtr
vramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrreeen

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ibzC (C:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibzC (C:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdglappqhlirvegnlrveylddrntfrhsvv
vpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvcac
pgrdrrreeenl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ibzD (D:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibzD (D:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrreeen