PDB entry 4ibz
View 4ibz on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R
Class: DNA binding protein
Keywords: metal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, DNA binding protein
Deposited on
2012-12-09, released
2013-08-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-15, with a file datestamp of
2017-11-10.
Experiment type: XRAY
Resolution: 1.92 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: P53, TP53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (179)
- engineered mutation (190)
Domains in SCOPe 2.08: d4ibza_ - Chain 'B':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: P53, TP53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (179)
- engineered mutation (190)
Domains in SCOPe 2.08: d4ibzb_ - Chain 'C':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: P53, TP53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (179)
- engineered mutation (190)
Domains in SCOPe 2.08: d4ibzc_ - Chain 'D':
Compound: Cellular tumor antigen p53
Species: Homo sapiens [TaxId:9606]
Gene: P53, TP53
Database cross-references and differences (RAF-indexed):
- Uniprot P04637
- engineered mutation (179)
- engineered mutation (190)
Domains in SCOPe 2.08: d4ibzd_ - Heterogens: ZN, EDO, ACT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4ibzA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg
Sequence, based on observed residues (ATOM records): (download)
>4ibzA (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvc
acpgrdrrreeen
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4ibzB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg
Sequence, based on observed residues (ATOM records): (download)
>4ibzB (B:)
vpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgtr
vramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrreeen
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4ibzC (C:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg
Sequence, based on observed residues (ATOM records): (download)
>4ibzC (C:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdglappqhlirvegnlrveylddrntfrhsvv
vpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvcac
pgrdrrreeenl
- Chain 'D':
Sequence, based on SEQRES records: (download)
>4ibzD (D:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrreeenlrkkg
Sequence, based on observed residues (ATOM records): (download)
>4ibzD (D:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrreeen