PDB entry 4ibw

View 4ibw on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R in sequence-specific complex with DNA
Class: DNA binding protein/DNA
Keywords: METAL-BINDING, LOOP-SHEET-HELIX MOTIF, TRANSCRIPTION, ACTIVATOR, ANTI-ONCOGENE, APOPTOSIS, CELL CYCLE, DISEASE MUTATION, RESCUE MUTATION, TUMOR SUPPRESSOR, DNA BINDING PROTEIN-DNA complex
Deposited on 2012-12-09, released 2013-08-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.79 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (0-199)
      • engineered mutation (179)
      • engineered mutation (190)
    Domains in SCOPe 2.08: d4ibwa_
  • Chain 'B':
    Compound: DNA (5'-d(*cp*gp*gp*gp*cp*ap*tp*gp*cp*cp*cp*g)-3')
  • Heterogens: ZN, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ibwA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevh
vcacpgrdrrreeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibwA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevhvca
cpgrdrrreeenlrkkg

  • Chain 'B':
    No sequence available.