PDB entry 4ibv

View 4ibv on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA
Class: DNA binding protein/DNA
Keywords: METAL-BINDING, LOOP-SHEET-HELIX MOTIF, TRANSCRIPTION, ACTIVATOR, ANTI-ONCOGENE, APOPTOSIS, CELL CYCLE, DISEASE MUTATION, RESCUE MUTATION, TUMOR SUPPRESSOR, DNA BINDING PROTEIN-DNA complex
Deposited on 2012-12-09, released 2013-08-14
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-08-14, with a file datestamp of 2013-08-09.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.165
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (0-199)
      • engineered mutation (146)
      • engineered mutation (179)
    Domains in SCOPe 2.03: d4ibva_
  • Chain 'B':
    Compound: DNA (5'-d(*cp*gp*gp*gp*cp*ap*tp*gp*cp*cp*cp*g)-3')
  • Heterogens: EDO, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ibvA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnrscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibvA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnrscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrteeenlrkkg

  • Chain 'B':
    No sequence available.