PDB entry 4ibq

View 4ibq on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R273C
Class: DNA binding protein
Keywords: metal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, DNA binding protein
Deposited on 2012-12-09, released 2013-08-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
    Domains in SCOPe 2.08: d4ibqa_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
    Domains in SCOPe 2.08: d4ibqb_
  • Chain 'C':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
    Domains in SCOPe 2.08: d4ibqc_
  • Chain 'D':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (179)
    Domains in SCOPe 2.08: d4ibqd_
  • Heterogens: ZN, ACT, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ibqA (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibqA (A:)
vpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgtr
vramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrteeen

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ibqB (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibqB (B:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvc
acpgrdrrteeen

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ibqC (C:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibqC (C:)
vpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgtr
vramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvca
cpgrdrrteeen

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ibqD (D:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevc
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >4ibqD (D:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihynymcnsscmggmnrrpiltiitledssgnllgrnsfevcvc
acpgrdrrteeen