PDB entry 4i8v

View 4i8v on RCSB PDB site
Description: Human Cytochrome P450 1A1 in complex with alpha-naphthoflavone
Class: oxidoreductase
Keywords: monooxygenase, cytochrome P450, P450, CYP1A1, P450 1A1,heme, oxidoreductase, aryl hydrocarbon hydroxylase
Deposited on 2012-12-04, released 2013-02-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-05-22, with a file datestamp of 2013-05-17.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.188
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4i8va_
  • Chain 'B':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04798 (7-484)
      • expression tag (6)
    Domains in SCOPe 2.07: d4i8vb1, d4i8vb2
  • Chain 'C':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4i8vc_
  • Chain 'D':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4i8vd_
  • Heterogens: HEM, BHF, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4i8vA (A:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8vA (A:)
glknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtirqa
lvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpasst
scyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrrydhnhqell
slvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktfek
ghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttaiswslmylvm
nprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftiphsttrdts
lkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekviifgmgkr
kcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfqmqlrs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4i8vB (B:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8vB (B:)
skglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtir
qalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpas
stscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrrydhnhqe
llslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktf
ekghirditdsliehcqekvqlsdekiinivldlfgagfdtvttaiswslmylvmnprvq
rkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftiphsttrdtslkgfy
ipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekviifgmgkrkcige
tiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfqmqlrs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4i8vC (C:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8vC (C:)
lknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtirqal
vrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpassts
cyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrrydhnhqells
lvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktfekg
hirditdsliehcqekqlsdekiinivldlfgagfdtvttaiswslmylvmnprvqrkiq
eeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftiphsttrdtslkgfyipkg
rcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekviifgmgkrkcigetiar
wevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfqmqlrs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4i8vD (D:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4i8vD (D:)
lknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtirqal
vrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpassts
cyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrrydhnhqells
lvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktfekg
hirditdsliehcqeqlsdekiinivldlfgagfdtvttaiswslmylvmnprvqrkiqe
eldtvigrsrrprlsdrshlpymeafiletfrhssfvpftiphsttrdtslkgfyipkgr
cvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekviifgmgkrkcigetiarw
evflflaillqrvefsvplgvkvdmtpiygltmkhaccehfqmqlrs