PDB entry 4i89
View 4i89 on RCSB PDB site
Description: Crystal structure of transthyretin in complex with diflunisal at acidic pH
Class: transport protein/inhibitor
Keywords: amyloidosis, fibrillogenesis inhibitor, transthyretin stabilizers, T4 or T3 hormone, plasma, transport protein-inhibitor complex
Deposited on
2012-12-03, released
2013-06-19
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-08-07, with a file datestamp of
2013-08-02.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.192
AEROSPACI score: 0.55
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: PALB, TTR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4i89a_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: PALB, TTR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4i89b_ - Heterogens: 1FL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4i89A (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgsspfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4i89A (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgsspfhehaevvftandsgprrytiaallspysysttavvtnp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4i89B (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgsspfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4i89B (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgsspfhehaevvftandsgprrytiaallspysysttavvtn