PDB entry 4i5l

View 4i5l on RCSB PDB site
Description: Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation
Class: hydrolase/toxin
Keywords: EF Hand, Phosphatase, CDC6 (Substrate), HYDROLASE-TOXIN complex
Deposited on 2012-11-28, released 2013-05-08
The last revision prior to the SCOPe 2.02 freeze date was dated 2013-05-15, with a file datestamp of 2013-05-10.
Experiment type: XRAY
Resolution: 2.43 Å
R-factor: 0.181
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d4i5la_
  • Chain 'B':
    Compound: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R3B, PPP2R3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d4i5lc_
  • Chain 'D':
    Compound: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R1A
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta - Cell division control protein 6 homolog chimeric construct
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2R3B, PPP2R3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP2CA
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Microcystin-LR (MCLR) bound form
    Species: Microcystis aeruginosa [TaxId:1126]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Chain 'H':
    Compound: Microcystin-LR (MCLR) bound form
    Species: Microcystis aeruginosa [TaxId:1126]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00109 (0-6)
  • Heterogens: PEG, CA, MN, MLI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4i5lA (A:)
gsmslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedev
llalaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdle
ahfvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraa
asklgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvm
ptlrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashk
vkefcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehl
lplflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiie
ympllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipk
vlamsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslq
kigpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

    Sequence, based on observed residues (ATOM records): (download) 
    >4i5lA (A:)
mslypiavlidelrnedvqlrlnsikklstialalgvertrsellpfltdtiydedevll
alaeqlgtfttlvggpeyvhcllppleslatveetvvrdkaveslraishehspsdleah
fvplvkrlaggdwftsrtsacglfsvcyprvssavkaelrqyfrnlcsddtpmvrraaas
klgefakvleldnvkseiipmfsnlasdeqdsvrllaveacvniaqllpqedlealvmpt
lrqaaedkswrvrymvadkftelqkavgpeitktdlvpafqnlmkdceaevraaashkvk
efcenlsadcrenvimsqilpcikelvsdanqhvksalasvimglspilgkdntiehllp
lflaqlkdecpevrlniisnldcvnevigirqlsqsllpaivelaedakwrvrlaiieym
pllagqlgveffdeklnslcmawlvdhvyaireaatsnlkklvekfgkewahatiipkvl
amsgdpnylhrmttlfcinvlsevcgqdittkhmlptvlrmagdpvanvrfnvakslqki
gpildnstlqsevkpilekltqdqdvdvkyfaqealtvlsla

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4i5lC (C:)
gsmdekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdv
hgqfhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnh
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtld
hiraldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvs
rahqlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrgep
hvtrrtpdyfl

    Sequence, based on observed residues (ATOM records): (download) 
    >4i5lC (C:)
dekvftkeldqwieqlneckqlsesqvkslcekakeiltkesnvqevrcpvtvcgdvhgq
fhdlmelfriggkspdtnylfmgdyvdrgyysvetvtllvalkvryreritilrgnhesr
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdgqifclhgglspsidtldhir
aldrlqevphegpmcdllwsdpddrggwgisprgagytfgqdisetfnhangltlvsrah
qlvmegynwchdrnvvtifsapnycyrcgnqaaimelddtlkysflqfdpaprrg

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.