PDB entry 4i24

View 4i24 on RCSB PDB site
Description: Structure of T790M EGFR kinase domain co-crystallized with dacomitinib
Class: transferase
Keywords: Kinase domain, Phosphotrasfer, ATP binding, TRANSFERASE
Deposited on 2012-11-21, released 2013-01-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-02-27, with a file datestamp of 2013-02-22.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.21
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (96)
    Domains in SCOPe 2.08: d4i24a_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (96)
    Domains in SCOPe 2.08: d4i24b_
  • Heterogens: 1C9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4i24A (A:)
gsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >4i24A (A:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelankeildeayvm
asvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakgmn
yledrrlvhrdlaarnvlvktpqhvkitdfglakllvpikwmalesilhriythqsdvws
ygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidadsrp
kfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvdad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4i24B (B:)
gsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >4i24B (B:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgkvpikwmalesilhri
ythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkc
wmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddv
vdad