PDB entry 4i22
View 4i22 on RCSB PDB site
Description: Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib
Class: transferase
Keywords: Kinase domain, Phosphotrasfer, ATP binding, TRANSFERASE
Deposited on
2012-11-21, released
2013-01-16
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-15, with a file datestamp of
2017-11-10.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: N/A
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533
- engineered mutation (96)
- engineered mutation (164)
- engineered mutation (254)
Domains in SCOPe 2.08: d4i22a_ - Heterogens: IRE, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4i22A (A:)
gsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipqqg
Sequence, based on observed residues (ATOM records): (download)
>4i22A (A:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelrkankeildeay
vmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakg
mnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllvpikwmalesilhriythqsdv
wsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidads
rpkfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvdad