PDB entry 4i0t
View 4i0t on RCSB PDB site
Description: Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide
Class: transferase/transferase inhibitor
Keywords: kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-11-19, released
2013-10-30
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-10-30, with a file datestamp of
2013-10-25.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.236
AEROSPACI score: 0.42
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase SYK
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4i0ta1, d4i0ta2 - Heterogens: 1B6, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4i0tA (A:)
maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdknii
elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvneghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4i0tA (A:)
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilpalkdellaeanvmqqld
npyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylees
nfvhrdlaarnvllvtqhyakisdfglskalradenyykawpvkwyapecinyykfssks
dvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydv
enrpgfaavelrlrnyyydvvneghh