PDB entry 4hx5
View 4hx5 on RCSB PDB site
Description: Crystal structure of 11 beta-HSD1 in complex with SAR184841
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: 11beta, hydroxysteroid, dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex
Deposited on
2012-11-09, released
2013-05-08
The last revision prior to the SCOPe 2.02 freeze date was dated
2013-05-08, with a file datestamp of
2013-05-03.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: 0.163
AEROSPACI score: 0.42
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Homo sapiens [TaxId:9606]
Gene: HSD11B1, HSD11, HSD11L
Database cross-references and differences (RAF-indexed):
- Uniprot P28845
- engineered mutation (265)
Domains in SCOPe 2.02: d4hx5a_ - Chain 'B':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Homo sapiens [TaxId:9606]
Gene: HSD11B1, HSD11, HSD11L
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (17-End)
- expression tag (13-16)
- engineered mutation (265)
- Chain 'C':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Homo sapiens [TaxId:9606]
Gene: HSD11B1, HSD11, HSD11L
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (17-End)
- expression tag (14-16)
- engineered mutation (265)
- Chain 'D':
Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
Species: Homo sapiens [TaxId:9606]
Gene: HSD11B1, HSD11, HSD11L
Database cross-references and differences (RAF-indexed):
- Uniprot P28845 (17-End)
- expression tag (13-16)
- engineered mutation (265)
- Heterogens: 19V, NDP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4hx5A (A:)
mkhqhqhqhqhqhqqplneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtar
sketlqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntsl
nlfhddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysas
kfaldgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleii
kggalrqeevyydsslwttllirnpsrkileflystsynmdrfink
Sequence, based on observed residues (ATOM records): (download)
>4hx5A (A:)
eefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaa
sahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnf
lsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvs
rvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwt
tllirnpsrkileflystsyn
- Chain 'B':
No sequence available.
- Chain 'C':
No sequence available.
- Chain 'D':
No sequence available.