PDB entry 4hvs
View 4hvs on RCSB PDB site
Description: Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647
Class: transferase/transferase inhibitor
Keywords: transferase, tyrosine-protein kinase, ATP-binding, kinase-kinase inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-11-06, released
2013-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-04-17, with a file datestamp of
2013-04-12.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.2
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Mast/stem cell growth factor receptor Kit
Species: Homo sapiens [TaxId:9606]
Gene: KIT, SCFR
Database cross-references and differences (RAF-indexed):
- Uniprot P10721 (9-End)
- expression tag (6-8)
- engineered mutation (21)
- engineered mutation (27)
- engineered mutation (67)
- engineered mutation (89)
- engineered mutation (109)
- engineered mutation (120)
- engineered mutation (148-149)
- engineered mutation (151-153)
- engineered mutation (156)
- engineered mutation (162)
- engineered mutation (225)
- engineered mutation (244)
- engineered mutation (290)
- engineered mutation (312)
- engineered mutation (323)
Domains in SCOPe 2.08: d4hvsa1, d4hvsa2 - Heterogens: 647, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4hvsA (A:)
mghhhhhhmpmyevqwkvveesngnnysyidptqlpydhkwefprnrlsfgktlgagafg
kvveataqgliksdaamtvavkmlkpsahsterealmselkvlsylgnhenivnllgact
hggptlviteyccygdllnflrrkrdsfhssdtspasmeddenaldledllsfsyqvakg
maflaskncihrdlaarnillthgritkicdfglardikndsnyvdkgnarlpvkwmape
sifnsvytfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmsspehapaem
ydimktcwdadpdkrptfkqivqdiekqisestnh
Sequence, based on observed residues (ATOM records): (download)
>4hvsA (A:)
hhmpmyevqwkvveesngnnysyidptqlpydhkwefprnrlsfgktlgagafgkvveat
aqgliksdaamtvavkmlkpsahsterealmselkvlsylgnhenivnllgacthggptl
viteyccygdllnflrrkrdsfhssdtspasmeddenaldledllsfsyqvakgmaflas
kncihrdlaarnillthgritkicdfglardikndsnyvdkgnarlpvkwmapesifnsv
ytfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmsspehapaemydimkt
cwdadpdkrptfkqivqdiekqises