PDB entry 4hvi

View 4hvi on RCSB PDB site
Description: JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((R)-1-methyl-2-oxo-2-piperidin-1-yl-ethyl)-amide
Class: Transferase/Transferase Inhibitor
Keywords: Kinase-Inhibitor Complex, Transferase-Transferase Inhibitor complex
Deposited on 2012-11-06, released 2013-01-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-01-30, with a file datestamp of 2013-01-25.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.238
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK3
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333
      • engineered mutation (237)
    Domains in SCOPe 2.08: d4hvia_
  • Heterogens: 19S, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hviA (A:)
cqdptifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqr
eiqilkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllys
sqickgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqsp
ifwyapeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgserdvpalsrl
lelleegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlwsgsrgcethaf
tahpegkhhslsfs

    Sequence, based on observed residues (ATOM records): (download) 
    >4hviA (A:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqgpdqqrdfqreiqilk
alhsdfivkyrgvsylrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeylgs
rrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwyapeslsdn
ifsrqsdvwsfgvvlyelftycdkscspsaeflrmmvpalsrllelleegqrlpappacp
aevhelmklcwapspqdrpsfsalgpqldmlwsg