PDB entry 4hqw

View 4hqw on RCSB PDB site
Description: Molecular tweezers modulate 14-3-3 protein-protein interactions
Class: transferase inhibitor
Keywords: 14-3-3, adapter protein, protein-protein interaction, transferase inhibitor
Deposited on 2012-10-26, released 2013-02-27
Made obsolete by 5oeh on 2017-07-26

The last revision prior to the SCOPe 2.05 freeze date was dated 2013-03-06, with a file datestamp of 2013-03-01.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.183
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein sigma
    Species: Homo sapiens [TaxId:9606]
    Gene: HME1, NM_006142, SFN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31947 (5-235)
      • expression tag (0-4)
    Domains in SCOPe 2.05: d4hqwa_
  • Heterogens: 19O, CL, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hqwA (A:)
gamgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggq
raawrvlssieqksneegseekgpevreyrekvetelqgvcdtvlglldshlikeagdae
srvfylkmkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglaln
fsvfhyeianspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt

    Sequence, based on observed residues (ATOM records): (download) 
    >4hqwA (A:)
gamgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggq
raawrvlssieqksnkgpevreyrekvetelqgvcdtvlglldshlikeagdaesrvfyl
kmkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfsvfhy
eianspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt