PDB entry 4hjo
View 4hjo on RCSB PDB site
Description: Crystal structure of the inactive EGFR tyrosine kinase domain with erlotinib
Class: transferase/transferase inhibitor
Keywords: Inactive Tyrosine Kinase Domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-10-13, released
2012-11-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-12-05, with a file datestamp of
2012-11-30.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.231
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Uniprot P00533
- engineered mutation (262)
Domains in SCOPe 2.08: d4hjoa_ - Heterogens: AQ4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4hjoA (A:)
mkkghhhhhggeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaik
elreatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvreh
kdnigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgae
ekeyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseiss
ilekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgde
rmhlpsptdsnfyralmdeedmddvvdadeylipqqg
Sequence, based on observed residues (ATOM records): (download)
>4hjoA (A:)
llrilketefkkikvlgsgafgtvykglwipvkipvaikelreatspkankeildeayvm
asvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmn
yledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwmalesi
lhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymi
mrkcwmidadsrpkfreliiefskmardpqrylviqgd