PDB entry 4heu
View 4heu on RCSB PDB site
Description: Crystal Structure of PDE10A with a biaryl ether inhibitor ((1-(3-(4-((1H-benzo[d]imidazol-2-yl)amino)phenoxy)pyridin-2-yl)piperidin-4-yl)methanol)
Class: hydrolase/hydrolase inhibitor
Keywords: PDE10A, inhibitors, phosphodiesterase 10A, biaryl ethers, hydrolase-hydrolase inhibitor complex
Deposited on
2012-10-04, released
2012-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-12-12, with a file datestamp of
2012-12-07.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.187
AEROSPACI score: 0.48
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Species: Homo sapiens [TaxId:9606]
Gene: PDE10A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4heua_ - Chain 'B':
Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Species: Homo sapiens [TaxId:9606]
Gene: PDE10A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4heub_ - Heterogens: ZN, SO4, 15J, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4heuA (A:)
tseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrf
imsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfs
nsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaii
atdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltand
iyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepl
lkacrdnlsqwekvirge
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4heuB (B:)
tseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrf
imsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfs
nsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaii
atdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltand
iyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepl
lkacrdnlsqwekvirge
Sequence, based on observed residues (ATOM records): (download)
>4heuB (B:)
ftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrfimsvkknyrr
vpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfsnsylqkfdhp
laalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfgn
rkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaegd
emkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepllkacrdnlsq
wekvirge