PDB entry 4he1

View 4he1 on RCSB PDB site
Description: Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with fructose-6-phosphate and phosphate
Class: hydrolase
Keywords: allosteric enzyme, HYDROLASE
Deposited on 2012-10-03, released 2013-10-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.23 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase isozyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00757
      • engineered mutation (31)
      • conflict (84)
    Domains in SCOPe 2.08: d4he1a_
  • Heterogens: F6P, PO4, MG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4he1A (A:)
tdrspfetdmltltryvmekgrqakgtgeltrllnsmltaikaissavrkaglahlygia
gsvnvtgdevkkldvlsnslvinmlqssystcvlvseenkdaiitakekrgkyvvcfdpl
dgssnidclasigtifaiyrktsedepsekdalqcgrnivaagyalygsatlvalstgqg
vdlfmldpalgefvlvekdvkikkkgkiyslnegyakyfdaatteyvqkkkfpedgsapy
garyvgsmvadvhrtlvyggiflypanqkspkgklrllyecnpvayiieqagglattgtq
pvldvkpeaihqrvplilgspedvqeyltcvqknqags

    Sequence, based on observed residues (ATOM records): (download) 
    >4he1A (A:)
mltltryvmekgrqakgtgeltrllnsmltaikaissavrkaglakldvlsnslvinmlq
ssystcvlvseenkdaiitakekrgkyvvcfdpldgssnidclasigtifaiyrktsede
psekdalqcgrnivaagyalygsatlvalstgqgvdlfmldpalgefvlvekdvkikkkg
kiyslnegyakyfdaatteyvqkkkfpedgsapygaryvgsmvadvhrtlvyggiflypa
nqkspkgklrllyecnpvayiieqagglattgtqpvldvkpeaihqrvplilgspedvqe
yltcvqknq